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Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented with 4-octyl itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.

Journal: Scientific Reports

Article Title: Protective role of IRG1/itaconate in acute myocardial injury: association with NLRP3 inflammasome and oxidative stress

doi: 10.1038/s41598-026-43821-0

Figure Lengend Snippet: Nrf2 pathway and oxidative stress were associated with IRG1/itaconate in acute myocardial injury. WT or IRG1 KO mice with acute myocardial injury were supplemented with 4-octyl itaconate (4-OI) and sacrificed 18 h post LPS exposure. ( A – D ) The levels of ROS, TBARS, the GSSG/GSH ratioin cardiac tissue homogenates and serum 8-OH-dG concentration were quantified ( n = 8). ( E , F ) Representative western blots and statistical analysis of IL-1β, NLRP3, Keap1, Nrf2, HO-1 and NQO1in heart samples were displayed ( n = 4). Data are representative of two independent experiments and show mean ± SD. ( A – D ) Two-way ANOVA with Sidak multiple comparison test. ( F ) two-sided t -test.

Article Snippet: The compound 4-Octyl itaconate (4-OI, #HY-112675) was sourced from MedChemExpress, USA.

Techniques: Concentration Assay, Western Blot, Comparison